Download e-book for kindle: Breast Cancer: Cellular and Molecular Biology by Martha R. Stampfer, Jack C. Bartley (auth.), Marc E.

By Martha R. Stampfer, Jack C. Bartley (auth.), Marc E. Lippman, Robert B. Dickson (eds.)

ISBN-10: 1461289750

ISBN-13: 9781461289753

ISBN-10: 1461317339

ISBN-13: 9781461317333

Where do you start to appear for a contemporary, authoritative article at the analysis or administration of specific malignancy? The few basic oncology textual content­ books are regularly outdated. unmarried papers in really expert journals are informative yet seldom finished; those are extra usually initial studies on a really constrained variety of sufferers. yes common journals fre­ quently post stable in-depth stories of melanoma themes, and released sym­ posium lectures are usually the simplest overviews to be had. regrettably, those studies and vitamins look sporadically, and the reader can by no means ensure whilst an issue of distinct curiosity may be lined. melanoma therapy and study is a sequence of authoritative volumes which objective to satisfy this want. it's an try to identify a serious mass of oncology literature masking almost all oncology subject matters, revised usually to maintain the insurance brand new, simply on hand on a unmarried library shelf or by means of a unmarried own subscription. now we have approached the matter within the following type. First, by means of divid­ ing the oncology literature into particular subdivisions corresponding to lung melanoma, genitourinary melanoma, pediatric oncology, and so on. moment, by means of asking eminent gurus in every one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor style is roofed in a quantity showing usually and predictably, discussing present prognosis, staging, markers, all different types of remedy modalities, simple biology, and more.

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In each of these cases, other loci on chromosome Up were not amplified, indicating that the amplification was not a result of polyploidy. Examination of the patient's history, the characteristics of the tumor, and the patient's prognosis showed that amplification of int-2 had a significant association (P < 2 x 10- 6 ) with the patients who subsequently developed a distal metastasis. Although, at the present time, we have no information on the spectrum of normal human tissues in which int-2 is expressed nor the effect of amplification on its expression, it seems probable that genetic alteration of this gene in murine and human breast tumors is more than coincidence.

9 '03 18 co u I 8 I I f-- "- I 0, 0 12 ~ CQ I I 13 ~ U I 1---- II II I 180 223 ~-~~--------~ r--- 86, 315 ---c>-- -If- - ~ ~--- 295 1---- 408 ---c>--"7',I ( • • ------1 Figure 3. A schematic representation of the deletions on the short arm of chromosome 11 in breast cancer patients. The order and distance between the markers on chromosome 11 p arc according to the recombination percentages listed in human gene mapping 8 (HGM8) [129]. Numbers between genetic loci refer to recombination percentages or distances in centimorgans.

In neuroblastoma, a similar correlation was found between the level of amplification of N-myc and very aggressive form of tumors [57]. Recently, Ali et al. [58,59] and van de Vijver et al. [60], have independently examined c-erb B-2 in separate panels of primary breast tumor DNAs. In our study, we found 12 of 122 tumor DNAs (10%) in which c-erb B-2 was amplified 2- to > l5-fold (Figure lC). In five of these tumor DNAs, the gene was amplified 2- to 5-fold, in another 5 tumors 6- to 15-fold, and in two tumors > l5-fold (Figure lC).

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Breast Cancer: Cellular and Molecular Biology by Martha R. Stampfer, Jack C. Bartley (auth.), Marc E. Lippman, Robert B. Dickson (eds.)

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