Ben Shen (auth.), Dr. Finian J. Leeper, Prof. Dr. John C.'s Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids PDF

By Ben Shen (auth.), Dr. Finian J. Leeper, Prof. Dr. John C. Vederas (eds.)

ISBN-10: 3540665730

ISBN-13: 9783540665731

This e-book is the second one of 2 volumes that care for discovery of chemical pathways of biosynthesis of average items (secondary metabolites). quantity 1 coated using isotopes in biosynthetic learn and the formation of enzyme cofactors and diminished polyketides. This moment quantity describes biosynthesis of fragrant (unreduced) polyketides, enzymes chargeable for cyclization of terpenoids (isoprenoids), and biochemical new release of chosen sessions of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). wisdom of the pathways and the innovations to explain them opens the door to combinatorial biosynthesis in addition to to the construction of certain pharmaceutical brokers using a mix of chemistry, molecular biology and protein biochemistry.

Show description

Read or Download Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids PDF

Similar biochemistry books

Download e-book for kindle: Human Brain Proteome by Lisa A. Neuhold (Eds.)

Proteomics is a scientific method for learning the identification and serve as of all proteins expressed in a mobilephone, tissue or organ. New drug objectives for illnesses are usually pointed out by way of evaluating the proteome of the ailment kingdom to the traditional country. therefore, proteomics has turn into more and more vital within the pharmaceutical and biotechnology industries in addition to teachers.

Read e-book online Fundamentals of Biochemistry: Life at the Molecular Level PDF

Content material: advent -- creation to the chemistry of lifestyles -- Water -- Biomolecules -- Nucleotides, nucleic acids, and genetic details -- Amino acids -- Proteins: basic constitution -- Proteins: three-d constitution -- Protein functionality: myoglobin and hemoglobin, muscle contraction, and antibodies -- Carbohydrates -- Lipids and organic membranes -- Membrane delivery -- Enzymes -- Enzymatic catalysis -- Enzyme kinetics, inhibition, and keep an eye on -- Biochemical signaling -- Metabolism -- creation to metabolism -- Glucose catabolism -- Glycogen metabolism and gluconeogenesis -- Citric acid cycle -- Electron shipping and oxidative phosphorylation -- Photosynthesis -- Lipid metabolism -- Amino acid metabolism -- Mammalian gas metabolism: integration and law -- Gene expression and replication -- Nucleotide metabolism -- Nucleic acid constitution -- DNA replication, fix, and recombination -- Transcription and RNA processing -- Protein synthesis -- legislation of gene expression

Get α-Gal and Anti-Gal: α1,3-Galactosyltransferase, α-Gal PDF

This can be an interdisciplinary publication which for the 1st time assembles the huge spectrum of knowledge at the easy and medical features of the typical anti-Gal antibody, the alpha-gal epitope and the enzyme generating it, alpha-1,3-galactosyltransferase. Anti-Gal is the main plentiful antibody in people, apes and previous global monkeys (monkeys of Asia and Africa).

Additional resources for Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids

Example text

Wakil SJ (1989) Biochemistry 28:4523 46 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. B. Shen Boom TV, Cronan JE (1989) Ann Rev Microbiol 43:317 Magnuson K, Jackowski S, Rock CO, Cronan JE (1993) Microbiol Rev 57:522 Carreras CW, Pieper R, Khosla C (1997) Top Cur Chem 188:85 Hopwood DA, Sherman DH (1990) Ann Rev Genet 24:37–66 Hopwood DA, Khosla C (1992) Ciba Foundation Sym 171:88 Pieper R, Kao C, Khosla C, Lou G, Cane DE (1996) Chem Soc Rev 297 Hopwood DA (1997) Chem Rev 97:2465 Ikeda H, Omura S (1997) Chem Rev 97:2591 Katz L (1997) Chem Rev 97:2557 Khosla C (1997) Chem Rev 97:2577 Staunton J, Wilkinson B (1997) Chem Rev 97:2611 Staunton J, Wilkinson B (1998) Top Curr Chem 195:49 Malpartida F, Hopwood DA (1994) Nature 309:462 Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F (1992) J Biol Chem 267:19,278 Motamedi H, Hutchinson CR (1987) Proc Natl Acad Sci USA 84:4445 Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR (1989) EMBO J 8:2727 Malpartida F, Hallam SE, Kieser HM, Motamedi H, Hutchinson CR, Butler MJ, Sugden DA, Warren M, McKillop C, Bailey CR, Humphreys GO, Hopwood DA (1987) Nature 325:818 Arrowsmith TJ, Malpartida F, Sherman DH, Birch A, Hopwood DA, Robinson JA (1992) Mol Gen Genet 234:254 Bibb MJ, Sherman DH, Omura S, Hopwood DA (1994) Gene 142:31–39 Blanco G, Brian P, Pereda A, Mendez C, Salas JA, Chater KF (1993) Gene 130:107 Butler MJ, Friend EJ, Hunter IS, Kaczmarek FS, Sugden DA, Warren M (1989) Mol Gen Genet 215:231 Dairi T, Hamano Y, Igarashi Y, Furumai T, Oki T (1997) Biosci Biotech Biochem 61:1445 Davis NK, Chater KF (1990) Mol Microbiol 4:1679 Decker H, Hagg S (1995) J Bacteriol 177:6126 Decker H, Rhor J, Motamedi H, Zahner H, Hutchinson CR (1995) Gene 166:121 Gould SJ, Hong ST, Carney JR (1998) J Antibiot 51:50 Grim A, Madduri K, Ali A, Hutchinson CR (1994) Gene 151:1 Hallam SE, Malaprtida F, Hopwood DA (1988) Gene 74:305 Han L, Yang K, Ramalingam E, Mosher RH, Vining LC (1994) Microbiology 140:3379 Hong ST, Carney JR, Gould SJ (1997) J Bacteriol 179:470 Ichinose K, Bedford DJ, Tornus D, Bechthold A, Bibb MJ, Revill WP, Floss HG, Hopwood DA (1998) Chem Biol 5:647 Kakinuma S, Ikeda H, Omura S (1991) Tetrahedron 47:6059 Kim ES, Bibb MJ, Butler MJ, Hopwood DA, Sherman DH (1994) Gene 141:141 Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA (1996) Gene 172:87 Niemi J, Ylihonko K, Hakala J, Parssinen R, Kopio A, Mantsala P (1994) Microbiology 140:1351 Sherman DH, Malpartida F, Bibb MJ, Kieser HM, Bibb MJ, Hopwood DA (1989) EMBO J 8:2717 Ye J, Dickens ML, Plater R, Li Y, Lawrence J, Strohl WR (1994) J Bacteriol 176:6270 Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P (1996) Mol Gen Genet 251:113 Yu TW, Bibb MJ, Revill PW, Hopwood DA (1994) J Bacteriol 176:2627 Seow KT, Meurer G, Gerlitz M, Wendt-Pienkowski E, Hutchinson CR, Davies J (1997) J Bacteriol 179:7360 Gaisser S, Trefzer A, Stockert S, Kirschning A, Bchthold A (1997) J Bacteriol 179:6271 Nowak-Thompson B, Gould SJ, Loper JE (1997) Gene 204:17 Beck J, Ripka S, Siegner A, Schiltz E, Schweizer E (1990) Eur J Biochem 192:487 Fujii I, Ono Y, Tada H, Gomi K, Ebizuka Y, Sankawa U (1996) Mol Gen Genet 253:1 Kimura N, Tsuge T (1995) J Bacteriol 175:4427 Minto RE, Townsend CA (1997) Chem Rev 97:2537 The Biosynthesis of Aromatic Polyketides 47 69.

Strohl WR (1997) Biotechnology of antibiotics, 2nd edn. Marcel Deckker, New York 8. Cragg GM, Newman DJ, Snader KM (1997) J Nat Prod 60:52 9. Hutchinson CR (1988) Med Res Rev 8:557 10. Katz L, Donadio S (1993) Ann Rev Microbiol 47:875 11. Hopwood DA (1993) Curr Opinion Biotechnol 4:531 12. Hutchinson CR (1994) Bio/Technol 12:375 13. Piepersberg W (1994) Crit Rev Biotechnol 14:251 14. Tsoi CJ, Khosla C (1995) Chem & Biol 2:355 15. Hutchinson CR, Fujii I (1995) Ann Rev Microbiol 49:201 16. Ikeda H, Omura S (1995) J Antibiot 48:549 17.

Dickens ML, Ye J, Strohl WR (1996) J Bacteriol 178:3384 83. Fu H, Ebert-Khosla S, Hopwood DA, Khosla C (1994) J Am Chem Soc 116:4166 84. Rajgarhia VB, Sttrohl WR (1997) J Bacteriol 179:2690 85. Alvarez MA, Fu H, Khosla C, Hopwood DA, Bailey J (1996) Nature Biotechnol 14:335 86. Fu H, Hopwood DA, Khosla C (1994) Chem Biol 1:205 87. McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C (1994) J Am Chem Soc 116:10,855 88. McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C (1995) Nature 375:549 89. Sherman DH, Bibb MJ, Simpson TJ, Johnson D, Malpartida F, Frenandez-Moreno M, Martinez E, Hutchinson CR, Hopwood DA (1991) Tetrahedron 47:6029 90.

Download PDF sample

Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids by Ben Shen (auth.), Dr. Finian J. Leeper, Prof. Dr. John C. Vederas (eds.)


by Thomas
4.3

Rated 4.18 of 5 – based on 44 votes