By Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge (auth.), Jos M. J. Lamers, Pieter D. Verdouw (eds.)
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Extra info for Biochemistry of Signal Transduction in Myocardium
Although several cardiomyopathies are associated with abnormal GPCR function, mutations are unlikely in these disorders. g. posttranslational modifications; effector regulation by ~'Y subunits; GTPase activating protein (GAP) activity of effectors; G protein expression levels etc. When comparing the regulation of G protein functional activity in cAMP and in inositol phosphate generating pathways, an extrapolation can be made to data on the status of these pathways in some cardiovascular diseases.
Cardiovasc Res 28: 1451-1460, 1994 5. Strader CD, Fong TM, Tota MR, Underwood D, Dixon RAF: Structure and function of G protein-coupled receptors. Annu Rev Biochem 63: 101-132,1994 6. Linder ME, Ewald DA, Miller RJ, Gilman AG: Purification and charaterization of GOa and three types of G;a after expression in Escherichia coli. J Bioi Chern 265: 8243-8251, 1990 7. Neer EJ: Heterotrimeric G proteins: Organizers of transmembrane signals. Cell 80: 249-257, 1995 8. Hansen CA, Schroering AG, Robishaw JD: Subunit expression of signal transducing G proteins in cardiac tissue: Implications for phospholipase C-beta regulation.
However, since it is an irreversible process, it has no regulatory function. Palmitoylation, on the contrary, is reversible. g. ,I a q) are palmitoylated at an amino-terminal cysteine residue. Depalmitoylation of a, has been observed after ~adrenoceptor stimulation. The depalmitoylated form was inactive and translocated to the cytosol [27, 28]. The precise significance of this mechanism is not clear yet. Phospholipase C-o In one recent study, the GPCR activation of phospholipase C-O has been shown, but the mechanism is still under speculation .
Biochemistry of Signal Transduction in Myocardium by Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge (auth.), Jos M. J. Lamers, Pieter D. Verdouw (eds.)