By Gerhard Krauss
This all-new version of a best-selling textual content has been completely up-to-date to maintain speed with the speedy growth in sign transduction research.
With didactic ability and readability, the molecular foundation of sign transduction, regulated gene expression, the cellphone cycle, tumorigenesis and apoptosis is made obvious for everybody with a easy wisdom in biochemistry or molecular biology.
"Valuable up to date info on biochemistry of sign transduction and regulation" (AFS)
"The transparent and didactic presentation makes it a textbook very worthy for college students and researchers no longer accustomed to all features of telephone regulation." (Biochemistry)
"This ebook is admittedly books: legislation and sign Transduction." (Drug Research)
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Extra info for Biochemistry of Signal Transduction and Regulation
B) The helix-loop-helix motif of the eucaryotic transcription factor Max complexed with DNA. Molscript drawing (Kraulis 1991). Fig. 8. Packing of the amino acids in the interior of a leucine zipper, after Ellenberger (1994), with permission. 12 1 The Regulation of Gene Expression lel bundle of 4 helices with two basic ends. As with the basic leucine zipper motif, the basic ends only attain a defined structure upon binding the DNA. The 4 helix bundle forms via dimerization of two subunits of the Max protein.
B) periodic arrangement of fingers in the major groove of the DNA. According Pabo and Sauer (1992), with permission. 2 Protein-Nucleic Acid Interactions as a Basis for specific Gene Regulation 9 Zinc Finger of the Steroid Hormone Receptor The DNA-binding of the steroid hormone receptor occurs via an approx. 2). The structure displays two so-called helix-loop-helix elements, each with a bound Zn2+ ion (Fig. 6). Both zinc ions are each complexed by 4 Cys residues, whereby a non-equivalent arrangement of the two Zn2+ ions is observed.
The entire process of gene expression in eucaryotes includes the following steps: > transcription: > conversion of the pre-mRNA into the mature mRNA which includes: > translation: formation of a primary transcript, the pre-mRNA Processing, splicing, transport from the nucleus to the cytosol synthesis of the protein on the ribosome. The expression of genes follows a tissue and cell-specific pattern, which determines the function and morphology of a cell. In addition, all development and differentiation events are also characterized by a variable pattern of gene expression.
Biochemistry of Signal Transduction and Regulation by Gerhard Krauss