Biased signaling in physiology, pharmacology and - download pdf or read online

By Brian J Arey

ISBN-10: 0124114601

ISBN-13: 9780124114609

ISBN-10: 0124115071

ISBN-13: 9780124115071

Biased Signaling in body structure, Pharmacology and Therapeutics is a distinct and crucial reference for the clinical group touching on how conformational-dependent activation is a typical phenomenon throughout many periods of receptors or signaling molecules. Written for either new and verified scientists in pharmacology, mobile biology, biochemistry, and sign transduction, in addition to physicians, this ebook sincerely explains biased signaling as an advanced mechanism for physiological platforms to decipher complicated signs from a restricted variety of signaling mechanisms. each one bankruptcy is devoted to another type of receptor and discusses the clinical foundation for biased signaling within the context of ways this information impacts pharmacology and will be used to enhance medicinal drugs and deal with ailment.

  • Offers a distinct and helpful source on biased receptor signaling that offers a world view for higher figuring out pharmacology throughout many receptor families
  • Integrates biased receptor signaling, body structure, and pharmacology to put this rising technology in the context of treating ailment
  • Includes very important chapters on either the pharmaceutical and healing implications of biased signaling

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Extra info for Biased signaling in physiology, pharmacology and therapeutics

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Nuclear receptors and their selective pharmacologic modulators. Pharmacol Rev 2013;65:710À78. 85. Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002;277:29355À293558. 86. Renauld J-C. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev Immunol 2003;3:667À76. 87. Wang X, Lupardus P, LaPorte SL, Garcia KC. Structural biology of shared cytokine receptors. Annu Rev Immunol 2009;27:29À60. 88. Schieve LA, Devine O, Boyle CA, Petrini JR, Warner L.

Is cooperative binding by hemoglobin really understood? Nat Struct Biol 1999;6:351À8. 60. Cui Q, Karplus M. Allostery and cooperativity revisited. Protein Sci 2008;17:1295À307. 61. Pauling L. The oxygen equilibrium of hemoglobin and its structural interpretation. Proc Natl Acad Sci 1935;21:181À91. 62. Onaran HO, Scheer A, Cotecchia S, Costa T. A look at receptor efficacy: from the signaling network of the cell to the intramolecular motion of the receptor. In: Kenakin T, Angus JA, editors. The Pharmacology of functional, biochemical and recombinant systems.

14 depicts some of the key aspects of understanding the pharmacological effects of ligands. Synthetic ligands that mimic the effects of the naturally occurring ligand, for example on signal transduction, are defined as agonists. Compounds that block, or antagonize, the effects of a naturally occurring ligand are said to be antagonists. The nature of a compound as an agonist or antagonist is determined by studying the effects of the compound on the biological end point in a concentrationÀresponse experiment.

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Biased signaling in physiology, pharmacology and therapeutics by Brian J Arey


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