Download PDF by C. A. Mims (auth.), D. A. J. Tyrrell (eds.): Aspects of Slow and Persistent Virus Infections: Proceedings

By C. A. Mims (auth.), D. A. J. Tyrrell (eds.)

ISBN-10: 9400993390

ISBN-13: 9789400993396

ISBN-10: 9400993412

ISBN-13: 9789400993419

This publication documents the papers and discussions at a piece­ store which came about in London at the fifth and sixth of April 1979, as a part of the programme of the fee of the eu groups on clinical and Public overall healthiness study. but the perspectives expressed are these of the members involved and never of the EEC or any of its organs. the article used to be to debate sure organic facets of traditional and experimental sluggish virus infections. as the volume of data and the focal point of curiosity various in recognize of every an infection the strategy and emphasis assorted additionally. when it comes to scrapie, we mentioned the character of the agent and the mode of pathogenesis, on the subject of SSPE, the hunt for strange gains of the virus, and up to date element­ ed paintings at the immunology of the disorder. As for Visna we reviewed the current figuring out of the virus and its pathogenicity and likewise box epidemiology and techniques for its keep an eye on. there have been additionally common papers, on interferon and oncornaviruses for instance. We thank all those that made the assembly attainable and enabled us to provide this ebook quick, in order that those that couldn't attend the assembly may possibly however be capable of learn loads of what went on at it. particularly we might thank the Ciba starting place who allowed us using their premises and Mrs. Jean Ashley who handled lots of the arrangements.

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Additional info for Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, held in London(U.K.), April 5–6, 1979

Example text

J Comp Pathol 84: 19-25, 1974. 27. Hourrigan, JL, hL Klingsporn, WW Clarke, M de Camp: Epidemiology of scrapie in the United States. In: Slow transmissible diseases of the nervous system, Hadlow, WJ, SB Prusiner (eds), New York, Academic Press, in press. 27 28. Pattison, IH, MN Hoare, IN Jebbett, WA Watson: Further observations on the production of scrapie in sheep by oral dosing with foetal membranes from scrapie-affected sheep. Br Vet J 130: lxv-lxvii, 1974. 29. Haralambiev, H, I Ivanova, A Vesselinova, K Mermerski: An attempt to induce scrapie in local sheep in Bulgaria.

Under such circumstances a sequence occurs in which, after a brief interval of a day or so, agent increases in titre in the lymphoreticular organs such as spleen (LRS) and reaches a plateau by around 3-4 weeks. Replication in the CNS commences at about 10 weeks and the titre continues to rise there until 34 c l inical and e v e ntually ter minal d iseas e superv e nes (Figur e 1) . c. injections to i mp ede the On th e other hand, disease onset (10) . - ton ea l replication . if an intraperi - (i .

Nature (New Biol) 237: 244-245, 1972. 58. Dickinson, AG, H Fraser, I McConnell, GW Outram, DI Sales, DM Taylor: Extraneural competition between different scrapie agents leading to loss of infectivity. Nature (London) 253: 556, 1975. 59. Kimberlin, RH, AG Dickinson: unpublished. 60. Fraser, H, AG Dickinson: Pathogenesis of scrapie in the mouse: the role of the spleen. Nature (London) 226: 462-463, 1970. 61. Clarke, MC, DA Haig: Multiplication of scrapie agent in mouse spleen. Res Vet Sci 12: 195-197, 1971.

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Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, held in London(U.K.), April 5–6, 1979 by C. A. Mims (auth.), D. A. J. Tyrrell (eds.)


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