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By Brian B. Hoffman

ISBN-10: 0674050886

ISBN-13: 9780674050884

Inducing highs of pleasure, anger, and terror, adrenaline fuels the extremes of human adventure. a hurry empowers superhuman feats in emergencies. Risk-taking junkies search to duplicate this sense in harmful recreations. And a surge could actually scare us to loss of life. Adrenaline brings us on top of things at the interesting molecule that drives a few of our so much effective experiences.

Adrenaline was once found in 1894 and speedy made its means out of the lab into clinics worldwide. during this engrossing account, Brian Hoffman examines adrenaline in all its capacities, from an essential regulator of physiological features to the topic of Nobel Prize–winning breakthroughs. simply because its biochemical pathways are prototypical, adrenaline has had common software in hormone study resulting in the improvement of robust new medicinal drugs. Hoffman introduces the scientists to whom we owe our figuring out, tracing the trails in their discoveries and aspirations and permitting us to understand the an important position adrenaline has performed in pushing sleek medication forward.

Hoffman additionally investigates the bright, from time to time lurid, position adrenaline occupies within the well known mind's eye, the place bills of its life-giving and deadly homes frequently go away the world of truth. recognized because the catalyst of the “fight or flight” reaction, adrenaline has additionally acquired forensic consciousness as an ideal poison, untraceable within the bloodstream—and rumors persist of its strength to restore the lifeless. precise to the spirit of its subject, Adrenaline is a stimulating trip that finds the reality in the back of adrenaline’s medical significance and enduring well known attraction.

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Dr. Oliver ascertained, or believed he had ascertained . . that glycerin extracts of some organs produce diminution in caliber of the arteries. .  No matter the validity of Oliver’s human experiments, they had enormous heuristic value, drawing him to definitive animal experiments in Schäfer’s laboratory. Ironically, Oliver’s inconclusive experiments in humans have been used in the twenty-first century as a putative example of how human research does not require confirmation in animals. In Sacred Cows and Golden Geese, Ray and Jean Greek state that Oliver and Schäfer’s animal experimentation only reproduced data already known.

However, Murray’s treatment of a patient with myxedema and Brown-Séquard’s provocative assertions focused considerable attention on the potential power of glandular extracts. These developments provided additional motivation to look for active substances in the adrenal glands. [ three ] A Country Doctor’s Remarkable Discovery Till I heard Chapman speak out loud and bold: Then felt I like some watcher of the skies When a new planet swims into his ken . . john keats In the early 1890s, numerous medical journals reported both the benefits of thyroid extracts in myxedema and Brown-Séquard’s rejuvenation claims.

Ruled by Glands 33 In 1893, many physicians still believed Addison’s disease only incidentally involved the adrenal glands. However, Murray’s treatment of a patient with myxedema and Brown-Séquard’s provocative assertions focused considerable attention on the potential power of glandular extracts. These developments provided additional motivation to look for active substances in the adrenal glands. [ three ] A Country Doctor’s Remarkable Discovery Till I heard Chapman speak out loud and bold: Then felt I like some watcher of the skies When a new planet swims into his ken .

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Adrenaline by Brian B. Hoffman


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